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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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Nanodiagnostic Attainments and Clinical Perspectives on C-Reactive Protein: Cardiovascular Disease Risks Assessment

Iswary Letchumanan1, M K Md Arshad1, Subash C B Gopinath1

  • 1Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia.

Current Medicinal Chemistry
|January 24, 2020
PubMed

Insights

Cardiovascular disease (CVD) diagnosis needs better biomarkers. This review explores advanced diagnostic techniques and the role of nanomaterials in developing high-performance detection methods for early CVD identification.

Area of Science:

  • Biomedical engineering
  • Clinical diagnostics
  • Cardiovascular research

Background:

  • Cardiovascular disease (CVD) is a leading cause of death globally, with ischemic heart disease being a major concern.
  • The rising CVD mortality rate necessitates improved early diagnostic tools.
  • Current diagnostic methods require enhancement for rapid and accurate outcomes.

Purpose of the Study:

  • To review current diagnostic strategies for cardiovascular disease.
  • To highlight the role of advanced technologies in developing high-performance detection methodologies.
  • To discuss the clinical significance of nanomaterials in medical diagnostics for CVD.

Main Methods:

  • Review of existing literature on CVD diagnostic techniques.
  • Analysis of various methods including surface plasmon resonance (SPR), colorimetric assays, ELISA, and electrical measurements.
  • Exploration of cutting-edge technologies and nanomaterial applications in diagnostics.

Main Results:

  • C-reactive protein (CRP) is a key biomarker for CVD diagnosis.
  • Diverse immunoassay and sensor technologies are employed for CVD detection.
  • Advanced techniques show promise for high-performance diagnostic methodologies.

Conclusions:

  • Early and rapid diagnosis of CVD is crucial for patient outcomes.
  • Nanomaterials offer significant potential for advancing CVD diagnostics and nanotheranostics.
  • Integration of novel technologies can improve the clinical significance of CVD detection.

Keywords:
C-Reactive proteinCardiovascular diseasebiosensorclinical biomarkerhighperformance detectionnanomaterial

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