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A Roadmap for the Development of Ivermectin as a Complementary Malaria Vector Control Tool
1, Peter Billingsley2, Fred Binka3
1Full List of Contributors in the Acknowledgments.
The American Journal of Tropical Medicine and Hygiene
|January 24, 2020
Summary
Mass drug administration of ivermectin shows promise for malaria control by reducing mosquito lifespan. This roadmap outlines steps for its community-level deployment against insecticide-resistant mosquitoes and residual transmission.
Area of Science:
- Global Health
- Vector-Borne Disease Control
- Malariology
Background:
- Insecticide resistance and residual malaria transmission necessitate novel control strategies.
- Ivermectin, an endectocide, demonstrates potential as a complementary vector control tool.
- The World Health Organization (WHO) has established preferred product characteristics for endectocides in vector control.
Framework:
- A roadmap details processes for ivermectin's integration as a vector control agent by 2024.
- Key considerations include optimal dosage for humans and livestock, and resistance risk assessment.
- Ethical, political, community engagement, and policy translation are crucial for deployment.
Implementation:
- Large-scale deployment strategies for ivermectin as a community-level preventive tool are addressed.
- Operational aspects of mass drug administration (MDA) are outlined.
- Multidisciplinary global health experts contributed to this strategic roadmap.
Implications:
- Ivermectin offers a novel mechanism of action to combat malaria.
- Successful implementation can counteract insecticide resistance and residual transmission.
- This initiative aims to contribute to the global eradication of malaria.
