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A Roadmap for the Development of Ivermectin as a Complementary Malaria Vector Control Tool.

¹, Peter Billingsley², Fred Binka³

¹Full List of Contributors in the Acknowledgments.

The American Journal of Tropical Medicine and Hygiene

|January 24, 2020

Summary

Mass drug administration of ivermectin shows promise for malaria control by reducing mosquito lifespan. This roadmap outlines steps for its community-level deployment against insecticide-resistant mosquitoes and residual transmission.

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Area of Science:

Global Health
Vector-Borne Disease Control
Malariology

Background:

Insecticide resistance and residual malaria transmission necessitate novel control strategies.
Ivermectin, an endectocide, demonstrates potential as a complementary vector control tool.
The World Health Organization (WHO) has established preferred product characteristics for endectocides in vector control.

Framework:

A roadmap details processes for ivermectin's integration as a vector control agent by 2024.
Key considerations include optimal dosage for humans and livestock, and resistance risk assessment.
Ethical, political, community engagement, and policy translation are crucial for deployment.

Implementation:

Large-scale deployment strategies for ivermectin as a community-level preventive tool are addressed.
Operational aspects of mass drug administration (MDA) are outlined.
Multidisciplinary global health experts contributed to this strategic roadmap.

Implications:

Ivermectin offers a novel mechanism of action to combat malaria.
Successful implementation can counteract insecticide resistance and residual transmission.
This initiative aims to contribute to the global eradication of malaria.