Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
Incomplete Dominance01:43

Incomplete Dominance

29.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.5K
Pleiotropy01:33

Pleiotropy

43.1K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.1K
Pedigree Analysis01:35

Pedigree Analysis

88.6K
Overview
88.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.7K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can Systemic Immunomodulatory Therapy Induce Remission of Atopic Dermatitis? A Systematic Review.

Journal of cutaneous medicine and surgery·2026
Same author

Multicytokine-based transcriptome-wide association study for 7 inflammatory skin disorders identifies candidate causal genes in keratinocytes.

The Journal of allergy and clinical immunology·2026
Same author

Serious infection risk with systemic treatments for psoriasis: A cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR).

The British journal of dermatology·2026
Same author

Evaluation of a Therapeutic Drug Monitoring Strategy for Adalimumab in Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.

Clinical and translational science·2026
Same author

Serious infection risk of certolizumab compared with other systemic therapies in women with psoriasis.

The British journal of dermatology·2026
Same author

Genetic proxies of GLP1R expression are associated with lower risk of psoriasis and psoriatic arthritis.

The British journal of dermatology·2026
Same journal

A Facial Lesion with Cord-like Induration and Ring-like Appearance on MRI: A Quiz.

Acta dermato-venereologica·2026
Same journal

Real-world Outcomes of Adalimumab in Hidradenitis Suppurativa: A 10-year Retrospective Longitudinal Study.

Acta dermato-venereologica·2026
Same journal

An 8-year-old Girl with Multiple Whitish Dots on the Hair Shaft: A Quiz.

Acta dermato-venereologica·2026
Same journal

A Congenital Subcutaneous Tumour of the Scalp in a Child: A Quiz.

Acta dermato-venereologica·2026
Same journal

Commentary on: "The Effects of Sun Exposure and Pigmentation Phenotype on Prognosis in Metastatic Melanoma".

Acta dermato-venereologica·2026
Same journal

Treatment Response to JAK Inhibitors in Long-standing Alopecia Areata (≥8 Years): A Real-world Observational Study.

Acta dermato-venereologica·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

704

Psoriasis and Genetics.

Nick Dand, Satveer K Mahil, Francesca Capon

    Acta Dermato-Venereologica
    |January 24, 2020
    PubMed
    Summary
    This summary is machine-generated.

    Recent genetic studies reveal the complex basis of psoriasis, a common inflammatory skin disease. Understanding genetic factors aids in classifying psoriasis subtypes and developing targeted treatments.

    Keywords:
    disease progressiongeneticsprecision medicinetreatment outcomepsoriasis

    More Related Videos

    Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
    10:31

    Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

    Published on: April 8, 2016

    15.0K
    Generation and Culturing of Primary Human Keratinocytes from Adult Skin
    10:42

    Generation and Culturing of Primary Human Keratinocytes from Adult Skin

    Published on: December 22, 2017

    17.2K

    Related Experiment Videos

    Last Updated: Dec 30, 2025

    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
    02:28

    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

    Published on: March 1, 2024

    704
    Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
    10:31

    Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

    Published on: April 8, 2016

    15.0K
    Generation and Culturing of Primary Human Keratinocytes from Adult Skin
    10:42

    Generation and Culturing of Primary Human Keratinocytes from Adult Skin

    Published on: December 22, 2017

    17.2K

    Area of Science:

    • Dermatology
    • Genetics
    • Immunology

    Background:

    • Psoriasis is a prevalent inflammatory skin condition influenced by genetic and environmental factors.
    • Elucidating the genetic underpinnings of psoriasis is crucial for understanding its pathogenesis.

    Purpose of the Study:

    • To review recent advancements in understanding the genetic basis of psoriasis.
    • To demonstrate the utility of genetic analysis for psoriasis stratification and treatment development.

    Main Methods:

    • Review of recent large-scale genome-wide association studies (GWAS).
    • Analysis of genetic contributions to psoriasis phenotypes and outcomes.
    • Integration of genetic data for informing therapeutic strategies.

    Main Results:

    • Genome-wide association studies have significantly advanced the understanding of psoriasis genetics.
    • Genetic analyses enable stratification of psoriasis by phenotype (plaque vs. pustular) and outcome (prognosis, comorbidities, treatment response).
    • Genetic insights are directly applicable to developing more effective psoriasis treatments.

    Conclusions:

    • Genetic research is pivotal in unraveling the complexities of psoriasis.
    • Stratification based on genetic data improves disease classification and prediction.
    • Genetic discoveries pave the way for precision medicine approaches in psoriasis management.