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An update on systemic therapy for penile cancer
Irene Resch1, Mohammad Abufaraj1,2,3, Nicolai A Hübner1
1Department of Urology, Medical University of Vienna, Vienna, Austria.
Current Opinion in Urology
|January 24, 2020
Summary
Systemic therapy for advanced penile squamous cell carcinoma (SCC) shows promise, particularly with chemotherapy and targeted agents. Further research is crucial due to the rarity of this cancer and the need for optimal treatment strategies.
Area of Science:
- Oncology
- Urology
- Cancer Research
Background:
- Advanced penile squamous cell carcinoma (SCC) has a poor prognosis despite systemic therapy advances.
- Lymph node metastases significantly impact treatment and survival in penile SCC patients.
Purpose of the Study:
- To provide an updated review of systemic therapy for penile SCC.
- To highlight recent data and future perspectives in penile SCC treatment.
Main Methods:
- Review of recent literature on systemic therapy for penile SCC.
- Analysis of data regarding chemotherapy, targeted therapies, and prognostic factors.
Main Results:
- Adjuvant chemotherapy improves survival in patients with pelvic lymph node metastases.
- Tyrosine kinase inhibitors show promising results in targeted therapy for penile SCC.
- A nomogram has been developed to predict overall survival based on perioperative chemotherapy.
Conclusions:
- Chemotherapy has moderate activity in advanced penile SCC, but optimal timing for lymph node metastases requires further clarification.
- Novel therapeutic targets are emerging, driven by understanding penile cancer pathogenesis.
- More research is essential due to the rarity of penile SCC, especially for recurrent or metastatic cases.
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