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Pectin and Zinc Alginate: The Right Inner/Outer Polymer Combination for Core-Shell Drug Delivery Systems.

Giulia Auriemma1, Andrea Cerciello1, Rita P Aquino1

  • 1Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano (SA), Italy.

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Summary
This summary is machine-generated.

New core-shell beads using pectin and alginate offer sustained betamethasone delivery. This colon-targeted system shows promise for inflammatory bowel disease (IBD) therapy.

Keywords:
betamethasonecore-shell particlesinflammatory bowel diseasenatural polysaccharides

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Developing effective drug delivery systems for colon-specific targeting remains a challenge.
  • Inflammatory Bowel Disease (IBD) requires localized treatment in the colon.
  • Core-shell particle systems offer potential for controlled and targeted drug release.

Purpose of the Study:

  • To develop and optimize core-shell beads for colon-targeted delivery of betamethasone.
  • To investigate the influence of process parameters on particle characteristics and drug release.
  • To evaluate the potential of these beads for treating inflammatory bowel disease.

Main Methods:

  • Co-axial prilling technique was employed for core-shell bead fabrication.
  • Pectin and alginate were used as polymeric carriers for betamethasone.
  • Optimization of feed solutions, polymer ratios, and process parameters was performed.
  • Characterization included micromeritics, inner structure, drug loading, and in vitro drug release studies in simulated biological fluids.

Main Results:

  • Uniform core-shell particles were reproducibly produced under optimized conditions.
  • The optimized formulation (F5) demonstrated sustained drug release characteristics.
  • A zinc-alginate gastro-resistant outer layer reduced early drug release in the upper gastro-intestinal tract.
  • The pectin core exhibited selectivity for colon delivery, enabling specific drug release in the colon.

Conclusions:

  • Optimized core-shell beads effectively encapsulate and deliver betamethasone.
  • The developed system provides colon-specific drug delivery, reducing premature release.
  • These particles represent a promising approach for colon-targeted drug delivery in inflammatory bowel disease therapy.