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Trends in Usage and Clinical Outcomes of Coronary Atherectomy: A Report From the National Cardiovascular Data
Nirat Beohar1,2, Lisa A Kaltenbach3, Daniel Wojdyla3
1NewYork-Presbyterian Hospital/Columbia University Medical Center (N.B., M.B.L., J.W.M., A.J.K.).
Insights
Coronary atherectomy (CA) use increased from 2009-2016, with higher hospital volumes linked to fewer major adverse cardiac events. However, increased CA use also correlated with a small rise in coronary perforation risk.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Health Services Research
Background:
- Adjunctive coronary atherectomy (CA) is used for severe calcified coronary lesions.
- Temporal trends, patient selection, and use variation of CA remain underdescribed.
- Understanding CA utilization patterns is crucial for optimizing percutaneous coronary intervention (PCI).
Purpose of the Study:
- To assess temporal trends in coronary atherectomy (CA) utilization.
- To evaluate interhospital variability in CA use.
- To determine the outcomes associated with CA in patients undergoing percutaneous coronary intervention (PCI).
Main Methods:
- Analysis of 3,864,377 patients undergoing PCI in the CathPCI Registry (July 2009–December 2016).
- Stratification of CA utilization by time intervals and hospital annual CA volumes.
- Primary outcome: in-hospital major adverse cardiac events (MACE) including mortality, myocardial infarction, or stroke.
Main Results:
- Coronary atherectomy (CA) constituted 1.7% of PCI procedures, with utilization increasing from 1.1% to 3.0% between 2009 and 2016.
- Higher hospital CA volumes were associated with reduced mortality and PCI failure/complication rates requiring coronary artery bypass grafting.
- An increase in CA utilization correlated with a temporal decline in MACE and myocardial infarction, but also a slight increase in coronary perforation.
Conclusions:
- Coronary atherectomy (CA) use is increasing despite infrequent application.
- Higher institutional CA volume is linked to improved patient outcomes, including lower mortality and fewer complications.
- The benefits of increased CA volume must be weighed against a small but significant risk of coronary perforation.
Background:
Adjunctive coronary atherectomy (CA) can be utilized in treating severely calcified coronary lesions; however, the temporal trends, patient selection, and variation in use of CA have not been well described. We sought to assess the trends in usage, interhospital variability, and outcomes with CA among patients undergoing percutaneous coronary intervention (PCI).
Methods:
All patients undergoing PCI in the National Cardiovascular Data Registry CathPCI Registry from July 1, 2009 to December 31, 2016 (N=3 864 377) were analyzed based on utilization of either rotational or orbital CA. Intervals using date of index CA grouped into 2009 Q3 to 2010, 2011 to 2012, 2013 to 2014, and 2015 to 2016 and hospital-level quartiles based on annual CA volumes were evaluated. The primary outcome measure was in-hospital major adverse cardiac events defined as a composite of all-cause mortality, periprocedural myocardial infarction, or stroke. Independent variables associated with outcomes were determined.
Results:
CA represented 1.7% (n=65 033) of the total PCI volume. Among hospitals performing PCI (n=1672), 577 (34.5%) did not perform any CA. Patients treated with CA were elderly, more often male, and had a history of diabetes, prior myocardial infarction, PCI, and coronary artery bypass grafting. The utilization of CA increased from 1.1% in Q3 2009 to 3.0% in Q4 of 2016 (5% quarterly increase in odds of CA; OR [95% CI], 1.05 [1.04-1.06], P<0.001). Among patients undergoing CA, there was a temporal decline in major adverse cardiac events (0.98 [0.97-0.99], P<0.001) and myocardial infarction (0.97 [0.96-0.98], P<0.001). In adjusted analyses, increasing hospital CA volume was associated with lower mortality (0.85 [0.76-0.96], P=0.01) and lower rates of PCI failure or complication requiring coronary artery bypass grafting (0.67 [0.56-0.79], P<0.001) but was associated with small increase in coronary perforation (1.18 [1.04-1.35], P<0.01).
Conclusions:
Although CA is performed infrequently, its use has increased over time. After accounting for potential confounders, higher CA volume was associated with lower risk of major adverse events counterbalanced by small risk of coronary perforation.
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