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Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for
N Brockdorff1, E M Fisher, S H Orkin
1Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.
Cytogenetics and Cell Genetics
|January 1, 1988
Abstract:
The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 beta subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus x M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosomes.