Catheter-Directed Thrombectomy for Highly Symptomatic Patients with Iliofemoral Deep Venous Thrombosis not Responsive to Conservative Treatment
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Published on: June 4, 2021
Daniel Kuetting1, Julian Luetkens2, Karsten Wolter2
1Department of Radiology, University of Bonn, Venusberg Campus 1, 53127, Bonn, Germany. daniel.kuetting@ukbonn.de.
Insights
Pharmacomechanical thrombectomy offers rapid pain relief for iliofemoral deep venous thrombosis (DVT) patients unresponsive to conservative care. This interventional technique demonstrates high patency rates and lasting symptom improvement, supported by angioplasty and stenting.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Cardiovascular Medicine
Background:
- Iliofemoral deep venous thrombosis (DVT) can cause significant morbidity.
- Conservative treatment is often insufficient for severe symptomatic cases.
- Pharmacomechanical thrombectomy remains under-investigated for refractory iliofemoral DVT.
Purpose of the Study:
- To evaluate the technical and clinical outcomes of pharmacomechanical thrombectomy for symptomatic iliofemoral DVT.
- To assess complications associated with the procedure.
- To compare outcomes with existing literature.
Main Methods:
- Retrospective analysis of 19 patients with iliofemoral DVT treated between 2013-2019.
- Pharmacomechanical thrombectomy ± thrombolysis was performed.
- Patients were followed for 12 months, assessing pain and Villalta scores.
Main Results:
- Successful thrombectomy in all 19 patients; no major complications.
- Significant reduction in pain (87%) and Villalta scores at 1 year.
- High iliofemoral vein patency (15/17) post-procedure with angioplasty and stenting.
Conclusions:
- Catheter-directed thrombectomy provides rapid, long-lasting pain relief for refractory iliofemoral DVT.
- Angioplasty and venous stenting post-thrombectomy achieve high patency rates.
- Pharmacomechanical thrombectomy is a viable option for severe iliofemoral DVT.
Purpose:
The use of pharmacomechanical thrombectomy in patients with symptomatic iliofemoral deep venous thrombosis (DVT) not responsive to conservative treatment is under-investigated until now. This prompted us to review and analyze our results (technical/clinical outcome, complications) and compare them to the current literature.
Materials And Methods:
Between 2013 and 2019, 19 patients (14 women and 5 men; mean age: 41.2 years, SD: 18.2) with iliofemoral DVT and excessive pain not responsive to conservative treatment were treated with pharmacomechanical thrombectomy. Patients were followed up for 12 months. Demographics, technical success and clinical outcome data (pain score/Villalta score) were collected.
Results:
Thrombectomy ± thrombolysis was successful in all cases (n = 19). No major complications were observed. Eight out of nineteen cases developed hematoma at the sheath insertion site not requiring further treatment. Seven out of nineteen cases required additional continuous lysis for complete iliofemoral clot solution. All patients received balloon angioplasty to treat post-thrombotic strictures. In 16/19 cases, stents were placed to preserve iliofemoral caliber and maintain unrestricted iliac venous outflow. Three patients (16%) required re-intervention due to re-thrombosis or in-stent stenosis after 4, 14 days and 4 months, respectively. Symptoms could be improved temporarily or indefinitely in 19 out of 19 patients. 1 year following thrombectomy mean pain score was reduced by 87%, mean Villalta score was 2.6 (SD: 4), and iliofemoral veins were patent in 15/17 patients.
Conclusion:
In symptomatic patients with iliofemoral DVT, refractory to conservative treatment, catheter-directed thrombectomy enables rapid and long-lasting pain relief. High patency rates can be achieved in patients receiving PTA and venous stenting post-thrombectomy.
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