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Cisapride stimulates propulsive motility patterns in human jejunum
G Coremans1, J Janssens, G Vantrappen
1Center for Gastrointestinal Research, University of Leuven, University Hospital Gasthuisberg, Belgium.
Digestive Diseases and Sciences
|December 1, 1988
Summary
Cisapride significantly enhances upper gut motility in healthy volunteers by increasing spike bursts and inducing peristaltic contractions. This prokinetic effect is crucial for propelling intestinal contents during the interdigestive state.
Area of Science:
- Gastroenterology
- Pharmacology
- Physiology
Background:
- Understanding upper gastrointestinal motility is crucial for diagnosing and treating motility disorders.
- Cisapride is a prokinetic agent known to affect gastrointestinal motility.
- Novel intraluminal electromyographic techniques allow for detailed study of gut electrical activity.
Purpose of the Study:
- To investigate the effects of cisapride on human upper gut motility.
- To characterize the electromyographic patterns induced by cisapride in the interdigestive state.
Main Methods:
- A placebo-controlled study involving seven healthy volunteers.
- Utilized a novel intraluminal electromyography technique to record gut electrical activity.
- Administered cisapride via a 10 mg intravenous bolus injection.
Main Results:
- Cisapride markedly increased the number of spike bursts in the interdigestive state.
- Observed a nonmigrating phase-3-like activity lasting 2.6 ± 0.4 minutes post-injection.
- Induced intense phase 2 activity with a tenfold increase in repetitive spike bursts and a sixfold increase in ultrarapid peristaltic rushes.
Conclusions:
- Cisapride induces a significant pattern of aborally propagated contractions in the human upper gut.
- These peristaltic contractions are likely responsible for active propulsion of intestinal contents during the interdigestive state.
- Cisapride demonstrates potent prokinetic effects on upper gastrointestinal motility.