Related Experiment Video
Updated: Dec 30, 2025

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Innovative Psychological Treatments for Depression
Steven D Hollon1, Christopher J Williams1
1Dr. Hollon is with the Department of Psychology, Vanderbilt University, Nashville, Tennessee (e-mail: steven.d.hollon@vanderbilt.edu). Dr. Williams is with the Department of Psychosocial Psychiatry, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, and president of the British Association for Behavioural and Cognitive Psychotherapies.
High-intensity psychosocial interventions offer effective and lasting relief for nonpsychotic depression, comparable to medications. Low-intensity approaches are emerging as a cost-effective way to meet the high demand for mental health services.
Area of Science:
- Psychiatry and Mental Health
- Clinical Psychology
Background:
- High-intensity psychosocial interventions demonstrate comparable efficacy and longer-lasting effects than pharmacotherapy for nonpsychotic depression.
- Advances in treatment selection strategies aim to personalize depression care.
- The substantial demand for mental health services exceeds the capacity of traditional high-intensity treatments.
Purpose of the Study:
- To highlight the efficacy of high-intensity psychosocial interventions for nonpsychotic depression.
- To discuss advancements in personalized treatment selection for depression.
- To introduce the development and potential of low-intensity interventions to address service demand.
Main Methods:
- Review of existing literature on psychosocial interventions for nonpsychotic depression.
- Analysis of strategies for optimizing treatment selection in depression.
- Exploration of emerging low-intensity intervention models.
Main Results:
- High-intensity psychosocial interventions are as effective and more enduring than medications for nonpsychotic depression.
- Personalized treatment selection methods have improved.
- Low-intensity interventions show promise for broad and cost-effective application.
Conclusions:
- Psychosocial interventions are a viable, enduring treatment for nonpsychotic depression.
- Addressing the high demand for depression services requires scalable, cost-effective solutions.
- Low-intensity interventions represent a promising avenue for expanding access to mental health care.
Related Concept Videos
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Cognitive Therapy
Antidepressant Drugs: MAOIs and Other Agents
Psychodynamic Therapy
Psychotherapy
Electroconvulsive Therapy

