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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
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Parkinson's Disease: Cognitive Impairment.

Joel Mack1, Laura Marsh1

  • 1Dr. Mack is with the Department of Psychiatry, Veterans Affairs Portland Health Care System and the Department of Psychiatry, Oregon Health & Science University, Portland, Oregon. Dr. Marsh is with the Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, and the Departments of Psychiatry and Neurology, Baylor College of Medicine, Houston, Texas. Send correspondence to Dr. Marsh (e-mail: laura.marsh2@va.gov).

Focus (American Psychiatric Publishing)
|January 25, 2020
PubMed
Summary

Cognitive deficits are a major concern for Parkinson

Keywords:
DementiaExecutive DysfunctionMild Cognitive ImpairmentParkinson’s

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Area of Science:

  • Neurology
  • Psychiatry
  • Neuroscience

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor abnormalities, mood disturbances, and psychotic symptoms.
  • Cognitive deficits are prevalent in PD, ranging from mild impairment to dementia, impacting daily functioning and quality of life.
  • The significance of cognitive dysfunction in PD is increasingly recognized, especially with advances in motor symptom treatments.

Purpose of the Study:

  • To highlight cognitive deficits as a critical clinical target for psychiatrists managing Parkinson's disease patients.
  • To emphasize the underdetection and undertreatment of cognitive dysfunction in clinical practice.
  • To advocate for a holistic approach to psychiatric care in PD, addressing cognitive impairment.

Main Methods:

  • Review of current understanding of cognitive deficits in Parkinson's disease.
  • Discussion of the clinical presentation, biopsychosocial features, and treatment of cognitive impairment in PD.
  • Exploration of future research and clinical care directions.

Main Results:

  • Cognitive impairment affects virtually all individuals with PD across all disease stages.
  • Cognitive deficits significantly impact functioning and quality of life, often more than motor symptoms.
  • Cognitive dysfunction is frequently underdetected and undertreated in clinical settings.

Conclusions:

  • Holistic psychiatric care for Parkinson's disease patients must include a thorough appreciation of cognitive impairment.
  • Addressing cognitive deficits is crucial for improving the overall well-being and psychiatric management of PD patients.
  • Further research and improved clinical strategies are needed for the detection and treatment of cognitive dysfunction in PD.