The interaction between cucurbit[8]uril and baicalein and the effect on baicalein properties

Area of Science:

• Supramolecular Chemistry
• Host-Guest Chemistry
• Chemical Spectroscopy

Background:

• Baicalein is a natural flavonoid with potential therapeutic properties.
• Cucurbit[8]uril is a macrocyclic host molecule known for its ability to form inclusion complexes.
• Understanding host-guest interactions is crucial for developing new drug delivery systems and modifying compound properties.

Purpose of the Study:

• To investigate the host-guest interactions between baicalein (BALE) and cucurbit[8]uril (Q[8]).
• To characterize the inclusion complex formed between BALE and Q[8].
• To determine how Q[8] influences the properties of BALE.

Main Methods:

• Proton Nuclear Magnetic Resonance (¹H NMR) spectroscopy
• Infrared (IR) spectroscopy
• Ultraviolet-visible (UV-vis) spectroscopy
• Differential Thermal Analysis (DTA)

Main Results:

• Evidence of a 1:1 inclusion complex formation between BALE and Q[8].
• Spectroscopic data indicate significant changes in BALE's properties upon complexation.
• DTA results further support the formation and stability of the inclusion compound.

Conclusions:

• Baicalein forms a stable 1:1 inclusion compound with cucurbit[8]uril.
• Cucurbit[8]uril effectively modifies the properties of baicalein through host-guest interactions.
• This complexation could have implications for baicalein's bioavailability and therapeutic applications.