Related Experiment Video
Updated: Dec 30, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
An Information Theoretic Approach to Model Selection: A Tutorial with Monte Carlo Confirmation
1Department of Psychology, Auburn University, Auburn, AL 36849 USA.
Abstract:
A reliance on null hypothesis significance testing (NHST) and misinterpretations of its results are thought to contribute to the replication crisis while impeding the development of a cumulative science. One solution is a data-analytic approach called Information-Theoretic (I-T) Model Selection, which builds upon Maximum Likelihood estimates. In the I-T approach, the scientist examines a set of candidate models and determines for each one the probability that it is the closer to the truth than all others in the set. Although the theoretical development is subtle, the implementation of I-T analysis is straightforward. Models are sorted according to the probability that they are the best in light of the data collected. It encourages the examination of multiple models, something investigators desire and that NHST discourages. This article is structured to address two objectives. The first is to illustrate the application of I-T data analysis to data from a virtual experiment. A noisy delay-discounting data set is generated and seven quantitative models are examined. In the illustration, it is demonstrated that it is not necessary to know the "truth" is to identify the one that is closest to it and that the most likely models conform to the model that generated the data. Second, we examine claims made by advocates of the I-T approach using Monte Carlo simulations in which 10,000 different data sets are generated and analyzed. The simulations showed that 1) the probabilities associated with each model returned by the single virtual experiment approximated those that resulted from the simulations, 2) models that were deemed close to the truth produced the most precise parameter estimates, and 3) adding a single replicate sharpens the ability to identify the most probable model.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
Propagation of Uncertainty from Systematic Error
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Interpretation of Confidence Intervals
Confidence intervals have confidence coefficients that are crucial for their interpretation. The most common confidence coefficients are 0.90, 0.95, and 0.99, which can be written as percentages–90%, 95%, and 99%, respectively.
Suppose a person calculates a confidence interval with a confidence coefficient of 0.95. In that case, they can...
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...

