Effects of Exercise Intensity on Acute Circulating Molecular Responses Poststroke
Pierce Boyne1, Colleen Meyrose1, Jennifer Westover1
1University of Cincinnati, Cincinnati, OH, USA.
Neurorehabilitation and Neural Repair
|January 25, 2020
Summary
High-intensity exercise, particularly with fast training speeds, boosts neuroplasticity molecules like BDNF and VEGF in stroke survivors. This suggests targeted exercise may enhance neurologic recovery after stroke.
Area of Science:
- Neuroscience
- Exercise Physiology
- Rehabilitation Medicine
Background:
- Exercise intensity's role in post-stroke functional recovery is unclear.
- Previous research indicated vigorous exercise increases brain-derived neurotrophic factor (BDNF) in stroke patients.
Purpose of the Study:
- To investigate the acute effects of different exercise intensities on circulating neuroplasticity-related molecules (VEGF, IGF1, cortisol) in chronic stroke.
- To re-examine brain-derived neurotrophic factor (BDNF) responses with updated analyses.
Main Methods:
- 16 participants with chronic stroke underwent three randomized exercise protocols: high-intensity interval training (HIT) on a treadmill, HIT on a seated stepper, and moderate-intensity continuous training (MCT) on a treadmill.
- Serum samples were analyzed for changes in VEGF, IGF1, cortisol, and BDNF.
- Mediation and effect modification analyses explored relationships between exercise parameters and molecular responses.
Main Results:
- Vascular-endothelial growth factor (VEGF) significantly increased with HIT-treadmill exercise.
- Insulin-like growth factor-1 (IGF1) increased during both HIT protocols.
- Blood lactate mediated the effects of HIT on BDNF and cortisol; peak treadmill speed mediated effects on BDNF and VEGF.
Conclusions:
- BDNF and VEGF are key serum markers for studying exercise intensity's impact on neurologic recovery.
- Fast training speed and anaerobic intensity are crucial for stimulating these neuroplasticity-related molecular responses.
- Observed differences in molecular responses based on gait speed subgroups may explain varied training responsiveness in stroke survivors.
Keywords:
brain-derived neurotrophic factorcortisolhigh-intensity interval traininginsulin-like growth factorlocomotionvascular endothelial growth factorMore Related Videos
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