Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

600
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
600
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

502
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
502
Menopause01:28

Menopause

3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Civic Engagement and Social Connectedness in Rural Communities: The Role of Sociodemographic Factors and Social Determinants of Health in Rural Areas of the United States.

Social sciences·2026
Same author

Reach and representativeness within a rural randomized controlled trial designed to improve community health through civic engagement for built environment change in Texas and New York.

Wellbeing, space and society·2026
Same author

Data-Driven Discovery of Plant-Based Dietary Subtypes and Their Association with Cancer, Cardiovascular diseases, and Type 2 diabetes in Postmenopausal Women: Insights from the Women's Health Initiative.

Journal of the Academy of Nutrition and Dietetics·2026
Same author

Development of a Patient Journey Map for Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Assessment of the Patient Journey in North America.

Journal of patient experience·2026
Same author

The Effect of Hunger on the Likelihood of Glucose Excursions in Adults with Overweight or Obesity: Continuous Glucose Monitoring and Ecological Momentary Assessment Observational Study.

JMIR formative research·2026
Same author

Low-fat dietary pattern and dementia mortality: a secondary analysis of the Women's Health Initiative dietary modification randomized clinical trial with long-term follow-up.

Menopause (New York, N.Y.)·2026
Same journal

Caregiver Burden at the Onset of Acute Hospital-At-Home.

Journal of the American Geriatrics Society·2026
Same journal

Utilization Patterns Among Heterogeneous Subgroups of Homebound Older Adults: A Latent Class Analysis.

Journal of the American Geriatrics Society·2026
Same journal

Off-Label Initiation of Gabapentin and Valproic Acid Among Long-Stay Nursing Home Residents With and Without Dementia.

Journal of the American Geriatrics Society·2026
Same journal

The DOAC-FRAIL Study-Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents.

Journal of the American Geriatrics Society·2026
Same journal

Practice Environment and Job Outcomes Among Primary Care Nurse Practitioners Caring for Patients With Dementia.

Journal of the American Geriatrics Society·2026
Same journal

Anticholinergic Medication Use in Veterans Affairs Long-Term Care Residents: Clinical Patterns and Opportunities for Deprescribing.

Journal of the American Geriatrics Society·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

7.0K

Postmenopausal Breast Cancer and Physical Function Change: A Difference-in-Differences Analysis.

Yvonne L Michael1, Chengyi Wu1, Kathy Pan2

  • 1Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania.

Journal of the American Geriatrics Society
|January 25, 2020
PubMed
Summary
This summary is machine-generated.

Breast cancer significantly accelerates physical function decline in postmenopausal women beyond normal aging. Invasive breast cancer and older age exacerbate these functional losses, highlighting the need for targeted survivorship care.

Keywords:
breast cancerdifference in differenceslongitudinalphysical function

More Related Videos

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

16.0K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.7K

Related Experiment Videos

Last Updated: Dec 30, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

7.0K
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

16.0K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.7K

Area of Science:

  • Gerontology
  • Oncology
  • Epidemiology

Background:

  • Breast cancer and its treatments can impact physical function (PF).
  • Existing research on breast cancer's effect on PF in postmenopausal women yields inconsistent findings.
  • This study aims to clarify the relationship between breast cancer and changes in PF.

Purpose of the Study:

  • To evaluate the impact of breast cancer on the change in physical function over time.
  • To compare PF changes in women with and without breast cancer.
  • To investigate how invasive status, stage, and age modify the effect of breast cancer on PF.

Main Methods:

  • Longitudinal cohort study utilizing the difference-in-differences (DID) method.
  • Inclusion criteria: Women aged 50-79 with four functional status assessments.
  • Comparison: 1636 women with breast cancer vs. 35,660 cancer-free women from the Women's Health Initiative.

Main Results:

  • Women with breast cancer exhibited a significantly greater decline in PF compared to cancer-free women (P < .0001).
  • The decline was most pronounced in women with invasive breast cancer (DID = -4.87).
  • Older women diagnosed with breast cancer experienced a more substantial PF decline.

Conclusions:

  • Breast cancer diagnosis leads to a significant decline in physical function, exceeding that of normal aging.
  • Distinguishing disease sequelae from aging is crucial for effective survivorship care.
  • A cancer-free comparison group is essential for accurate interpretation of PF changes in breast cancer patients.