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Updated: Jun 27, 2026
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Single-Layered Graphene/Au-Nanoparticles-Based Love Wave Biosensor for Highly Sensitive and Specific Detection of
Junwang Ji1, Yiquan Pang2, Dongxiao Li1
1Key Laboratory of Optoelectronic Technology & Systems, Ministry of Education, International R & D Center of Micro-nano Systems and New Materials Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China.
Abstract:
In this work, a single-layered graphene (SLG)/Au-nanoparticles (NPs)-based Love wave biosensor was prepared for detection of Staphylococcus aureus (S. aureus) gene sequences. The annealing process was proposed to obtain a larger-area interface with ssDNA. The sensitivity was verified by detecting S. aureus gene sequences with a linear detection ranging from 0 to 10 nmol/L, where the limit of detection (LOD) was only 12.4 pg/mL. The stable state of the biosensors based on SLG/Au NPs in the liquid phase could be kept for more than 0.5 h (±0.1°), and the specificity was verified by detecting noncomplementary ssDNA and one- and three-base mismatched ssDNA. The results of our study suggest that a Love wave biosensor based on SLG/Au NPs hold great potential in clinical testing and diagnosis.
