Related Experiment Video
Updated: Dec 30, 2025
06:07
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
2.8K
HIV, aging, and adherence: an update and future directions
Sarah Czarna Mann1, Jose R Castillo-Mancilla
1Division of Infectious Diseases, School of Medicine, University of Colorado-AMC, Aurora, Colorado, USA.
Current Opinion in HIV and AIDS
|January 25, 2020
Summary
Older individuals living with HIV show high antiretroviral therapy (ART) adherence. Research gaps persist in understanding how aging affects adherence and pharmacokinetics in this growing population.
Area of Science:
- Geriatric Medicine
- Infectious Diseases
- Pharmacology
Background:
- The population of people living with HIV (PLWH) is aging.
- Understanding age-related factors in HIV treatment is crucial.
Purpose of the Study:
- Review recent data on antiretroviral adherence in older PLWH.
- Describe relevant antiretroviral pharmacokinetic studies.
- Identify research gaps in this demographic.
Main Methods:
- Literature review of antiretroviral adherence and pharmacokinetics in older PLWH.
- Analysis of studies using various adherence measurement tools.
- Evaluation of pharmacokinetic data in aging populations.
Main Results:
- Older PLWH generally demonstrate higher antiretroviral therapy (ART) adherence.
- No significant pharmacokinetic differences observed between older and younger PLWH.
- Current adherence measures lack a gold standard for older patients.
Conclusions:
- Aging's impact on adherence and pharmacokinetics requires further investigation.
- More research is needed on toxicity, drug interactions, and comorbidities in aging PLWH.
- Clinical trials must include older PLWH to inform treatment guidelines.
Related Concept Videos
01:10Retrovirus Life Cycles
49.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.0K
01:26Sexually Transmitted Infections
782
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
782