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Neoadjuvant Approaches Prior To Radical Prostatectomy
Stephen T Ryan1, Devin N Patel2, J Kellogg Parsons2
1From the Maine Medical Center, Portland, ME.
Cancer Journal (Sudbury, Mass.)
|January 25, 2020
Summary
Neoadjuvant androgen-deprivation therapy (ADT) before prostate cancer surgery shows promise. Novel hormonal agents may improve long-term survival for localized prostate cancer patients receiving neoadjuvant therapy.
Area of Science:
- Oncology
- Urology
Background:
- High-risk localized prostate cancer requires multimodality therapy for curative intent.
- Androgen-deprivation therapy (ADT) combined with radiation improves survival.
- Previous neoadjuvant ADT and surgery trials lacked consistent survival benefits.
Purpose of the Study:
- To review advances in neoadjuvant therapy for prostate cancer.
- To evaluate emerging data on neoadjuvant therapy before radical prostatectomy.
Main Methods:
- Literature review of recent advances in neoadjuvant approaches.
- Analysis of emerging clinical trials data.
Main Results:
- Novel hormonal agents offer new potential for neoadjuvant therapy.
- Emerging data supports neoadjuvant therapy prior to radical prostatectomy.
Conclusions:
- Neoadjuvant therapy, particularly with newer hormonal agents, warrants further investigation for localized prostate cancer.
- Optimizing neoadjuvant strategies may improve long-term outcomes for high-risk prostate cancer patients.
