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Published on: April 14, 2014
Correlation of Visual Quality of Life With Clinical and Visual Status in Friedreich Ataxia
Parisa Afsharian1, Rachel Nolan-Kenney, Abigail E Lynch
1Division of Neurology (PA, AL, DRL), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and Departments of Neurology (RN-K, LJB), Population Health and Ophthalmology, NYU School of Medicine, Sackler Institute of Graduate Biomedical Sciences, New York, New York.
Background:
The primary objective was to determine the association of patient-reported vision-specific quality of life to disease status and visual function in patients with Friedreich's ataxia (FRDA).
Methods:
Patients with FRDA were assessed with the 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) along with measures of disease status (ataxia stage) and visual function (low- and high-contrast letter acuity scores). The relations of NEI-VFQ-25 scores to those for disease status and visual function were examined.
Results:
Scores for the NEI-VFQ-25 were lower in patients with FRDA (n = 99) compared with published disease-free controls, particularly reduced in a subgroup of FRDA patients with features of early onset, older age, and abnormal visual function.
Conclusions:
The NEI-VFQ-25 captures the subjective component of visual function in patients with FRDA.
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