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Lights on MsFLASH: a review of contributions

Susan D Reed1, Andrea Z LaCroix2, Garnet L Anderson3

  • 1Obstetrics and Gynecology/Epidemiology, University of Washington, Seattle, WA.

Menopause (New York, N.Y.)
|January 25, 2020
PubMed
Abstract

Insights

Certain medications like escitalopram and venlafaxine significantly reduced hot flashes in menopausal women. Cognitive behavioral therapy improved insomnia, but yoga and omega-3 supplements showed no benefit for vasomotor symptoms.

Area of Science:

  • Reproductive Medicine
  • Clinical Trials
  • Women's Health

Background:

  • Menopause significantly impacts women's quality of life due to bothersome symptoms.
  • Effective and safe treatment options for menopausal symptoms are crucial.

Purpose of the Study:

  • To investigate the efficacy of various interventions for common menopausal symptoms.
  • To provide evidence-based recommendations for managing menopause.

Main Methods:

  • Conducted five randomized clinical trials and three ancillary studies.
  • Included over 1,300 women across multiple study sites.
  • Assessed interventions for vasomotor, sleep, and vaginal symptoms, quality of life, sexual function, and mood.

Main Results:

  • Escitalopram, venlafaxine, and low-dose estradiol significantly reduced hot flashes by ~50% compared to placebo (~30%).
  • Cognitive behavioral therapy for insomnia improved sleep quality and reduced insomnia symptoms.
  • Yoga, exercise, omega-3 supplements, vaginal estradiol, and vaginal moisturizer showed no significant benefit over control/placebo for respective symptoms.

Conclusions:

  • The MsFLASH trials provided substantial insights into menopausal symptom management.
  • Clinicians should consider both hormonal and nonhormonal therapies when counseling patients.

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