Related Experiment Video
Updated: Dec 30, 2025
Knee Arthrocentesis in Adults
Published on: February 25, 2022
Periarticular Ketorolac Improves Outcomes for Patients With Joint Replacements
Laura Sasse1,2,3, Betsy Laessig-Stary1,2,3, Tracey Abitz1,2,3
1Laura Sasse, ND, RN, ONC, Clinical Nurse Specialist, Orthopedics and General Surgery, University Hospital, UW Health, Madison, WI.
Background:
Effective analgesia after joint replacement allows for earlier mobilization, decreased length of stay, and reduced opioid use. The injection of the surgical area with ketorolac (Toradol) prior to closure has changed pain management in joint replacement surgery.
Purpose:
This retrospective research study examined the difference between patients who received periarticular injections of ketorolac versus those who did not. Postoperative outcomes were measured in the two groups.
Methods:
Between January 2012 and December 2014, a random sample of 161 patient charts was reviewed to compare length of stay, distance ambulated in the first physical therapy (PT) session, and amount of opioids consumed.
Results:
Ketorolac injected into the tissue prior to closure significantly impacted outcomes. Patients who received the injection had statistically significant shorter stays, ambulated further distances with their first PT session, and used fewer opioids on postoperative day 1.
Conclusion:
Periarticular ketorolac injections reduce pain and improve outcomes, which reduces healthcare costs.
