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D-dimer and diffusion-weighted imaging pattern as two diagnostic indicators for cancer-related stroke: A case-control
Yijun Shen1,2, Yuxia Li3, Chengming Chen4
1Department of Neurology, Xin Hua Hospital Chongming Branch Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai.
Medicine
|January 25, 2020
Summary
Cancer-associated ischemic stroke in East Asia shows unique characteristics, including high D-dimer levels and multiple vascular lesions. These findings suggest D-dimer and diffusion-weighted imaging (DWI) can aid in clinical diagnosis.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Cancer-associated ischemic stroke (CSIS) presents distinct clinical features compared to conventional ischemic stroke.
- Understanding these differences is crucial for accurate diagnosis and management in East Asian populations.
Purpose of the Study:
- To evaluate risk factors and clinical characteristics of CSIS.
- To differentiate CSIS from conventional ischemic stroke in China and East Asia.
Main Methods:
- Retrospective analysis of 609 stroke patients with cancer (June 2012-June 2016).
- Comparison of cancer-stroke group (CSG) with stroke group (SG) and cancer group (CG).
- Analysis of D-dimer levels and diffusion-weighted imaging (DWI) lesion patterns.
Main Results:
- Colorectal and lung cancers were most common.
- CSG exhibited significantly higher D-dimer levels and distinct DWI patterns compared to other groups.
- Elevated D-dimer levels were observed in lung, pancreas, and gastric cancers.
Conclusions:
- CSIS is characterized by high plasma D-dimer levels and multiple vascular lesions.
- D-dimer and DWI patterns serve as valuable diagnostic indices for CSIS.
