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Rat endomyocardial disease: a neural origin?
C Landes1, H J Ruefenacht, D C Naylor
1Ciba-Geigy AG, Basel, Switzerland.
Experimental Pathology
|January 1, 1988
Summary
Cardiac lesions in rats likely originate from neural cells. Most lesions, including tumors, stained positive for S-100 protein and neuron-specific enolase, suggesting a neural origin for endomyocardial disease.
Area of Science:
- Cardiovascular pathology
- Neurobiology
- Oncology
Background:
- Endomyocardial disease in Sprague-Dawley rats can progress to tumor formation.
- The cellular origin of these cardiac lesions is not fully understood.
Purpose of the Study:
- To investigate the cellular origin of cardiac lesions in Sprague-Dawley rats.
- To determine if these lesions share markers with neural tissues.
Main Methods:
- Histopathological examination of 58 cardiac lesions from rats.
- Immunohistochemical staining for S-100 protein.
- Immunohistochemical staining for neuron-specific enolase on selected cases.
Main Results:
- The majority of cardiac lesions, including 10 tumors, showed positive staining for S-100 protein.
- Duplicate sections from selected cases also reacted positively for neuron-specific enolase.
- These findings were observed across different stages of endomyocardial disease.
Conclusions:
- The positive staining for neural markers suggests a probable neural origin for these cardiac lesions.
- The study provides evidence supporting a neurogenic hypothesis for endomyocardial disease progression to tumors in this rat model.