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Rat endomyocardial disease: a neural origin?

C Landes¹, H J Ruefenacht, D C Naylor

¹Ciba-Geigy AG, Basel, Switzerland.

Experimental Pathology

|January 1, 1988

Summary

Cardiac lesions in rats likely originate from neural cells. Most lesions, including tumors, stained positive for S-100 protein and neuron-specific enolase, suggesting a neural origin for endomyocardial disease.

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Area of Science:

Cardiovascular pathology
Neurobiology
Oncology

Background:

Endomyocardial disease in Sprague-Dawley rats can progress to tumor formation.
The cellular origin of these cardiac lesions is not fully understood.

Purpose of the Study:

To investigate the cellular origin of cardiac lesions in Sprague-Dawley rats.
To determine if these lesions share markers with neural tissues.

Main Methods:

Histopathological examination of 58 cardiac lesions from rats.
Immunohistochemical staining for S-100 protein.
Immunohistochemical staining for neuron-specific enolase on selected cases.

Main Results:

The majority of cardiac lesions, including 10 tumors, showed positive staining for S-100 protein.
Duplicate sections from selected cases also reacted positively for neuron-specific enolase.
These findings were observed across different stages of endomyocardial disease.

Conclusions:

The positive staining for neural markers suggests a probable neural origin for these cardiac lesions.
The study provides evidence supporting a neurogenic hypothesis for endomyocardial disease progression to tumors in this rat model.

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