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Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Antibody Structure and Classes01:25

Antibody Structure and Classes

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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Cross-reactivity00:42

Cross-reactivity

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Related Experiment Video

Updated: Dec 30, 2025

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

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Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires.

Bryan S Briney, Jordan R Willis, Jessica A Finn

    Plos One
    |January 25, 2020
    PubMed
    Summary
    This summary is machine-generated.

    This study corrects a previously published article DOI. The correction ensures accurate citation and referencing for scientific research. This ensures the integrity of the scientific record.

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    Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice
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    Area of Science:

    • Bibliometrics
    • Scientific Communication

    Context:

    • Correction of a published article's Digital Object Identifier (DOI).
    • Ensuring accurate referencing and citation practices in scientific literature.

    Purpose:

    • To rectify an error in the article DOI: 10.1371/journal.pone.0100839.
    • To maintain the integrity and retrievability of scientific publications.

    Summary:

    • The article DOI has been corrected to ensure proper identification.
    • This correction facilitates accurate citation and access to the research.

    Impact:

    • Improves the accuracy of scientific databases and citation indexes.
    • Supports reliable scientific communication and knowledge dissemination.