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A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
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Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.

Kazuki Nakawatari1, Makoto Kurano2, Osamu Araki3

  • 1Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 25, 2020
PubMed
Summary
This summary is machine-generated.

Serum phosphatidylserine-specific phospholipase A1 (PS-PLA1) levels are elevated in Graves' disease and other thyroid disorders, suggesting PS-PLA1 as a potential therapeutic target and diagnostic marker for hyperthyroidism.

Keywords:
Anti-thyroid drugsGraves’ diseaseHyperthyroidismLysophosphatidylserinePhosphatidylserine-specific phospholipase A1Thyroid hormones

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Area of Science:

  • Biochemistry
  • Immunology
  • Endocrinology

Background:

  • Lysophosphatidylserine, a lipid mediator, is implicated in immune responses.
  • A specific receptor polymorphism for lysophosphatidylserine is linked to Graves' disease.
  • The role of lysophosphatidylserine in thyroid disorders requires further investigation.

Purpose of the Study:

  • To investigate the association between phosphatidylserine-specific phospholipase A1 (PS-PLA1) levels and thyroid disorders.
  • PS-PLA1 is an enzyme that produces lysophosphatidylserine.

Main Methods:

  • Serum PS-PLA1 levels were measured in 120 patients with thyroid disorders and 58 healthy controls.
  • Correlations between PS-PLA1 levels and thyroid hormone levels were analyzed.

Main Results:

  • Elevated serum PS-PLA1 levels were observed in patients with Graves' disease, subacute thyroiditis, and silent thyroiditis.
  • PS-PLA1 levels were not significantly altered in hypothyroidism.
  • PS-PLA1 levels correlated strongly with thyroid hormone levels, particularly in Graves' disease.
  • Treatment for Graves' disease reduced PS-PLA1 levels, with changes correlating with thyroid hormone fluctuations.

Conclusions:

  • PS-PLA1 may represent a novel therapeutic target for hyperthyroidism, especially Graves' disease.
  • PS-PLA1 measurement could serve as a supplementary diagnostic tool for assessing thyroid function.