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Published on: April 10, 2018
Can small nucleolar RNA be a novel molecular target for hepatocellular carcinoma?
Han Shuwen1, Yang Xi2, Qi Quan3
1Department of Oncology, Huzhou Cent Hosp, Affiliated Cent Hops HuZhou University, 198 Hongqi Rd, Huzhou, Zhejiang, PR China.
Background:
Globally, hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. Recently, many studies have demonstrated that small nucleolar RNA (snoRNA) was closely related to HCC.
Objective:
To explore whether snoRNA can be used as a molecular target for HCC.
Methods:
The PubMed, Embase, and Cochrane databases were searched for the published literatures related to snoRNA and HCC until August 12, 2019. After identification, screening, and verification, this study finally included 26 studies correlating small nucleolar RNA host gene (SNHG) and HCC, and 8 studies correlating snoRNA and HCC. Based on the collation of the relevant literature, the correlation network diagram between snoRNAs and HCC was constructed.
Results:
The SNHGs, such as SNHG1, SNHG6, SNHG16, and SNHG20 can play varied roles in HCC through different regulatory mechanisms. These SNHGs can promote and inhibit tumorigenesis. SNORD76 can promote the proliferation of tumor tissues and cells in vitro through different pathways. SnoU2_19 and SNORD76 can function through the same pathway. SNHG3, SNHG20, SNHG6, SNORD76, and snoRA47 can modulate epithelial-mesenchymal transition (EMT) to regulate the development of HCC cell or tissue. SNHG16, SNORD76, and SnoU2_19 can regulate the development of HCC through Wnt/β-catenin signaling pathway.
Conclusion:
snoRNA can regulate the occurrence of HCC by modulating multiple molecular signaling pathways. Hence, snoRNA can be a potential molecular target for HCC.
Insights
Small nucleolar RNAs (snoRNAs) are linked to hepatocellular carcinoma (HCC). These molecules, including small nucleolar RNA host genes (SNHGs), can influence tumor development and represent potential therapeutic targets for HCC.
Area of Science:
- Oncology
- Molecular Biology
- RNA Biology
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide.
- Emerging research indicates a significant association between small nucleolar RNAs (snoRNAs) and HCC development.
Purpose of the Study:
- To investigate the potential of snoRNAs as molecular targets for hepatocellular carcinoma.
- To elucidate the role of specific snoRNAs and small nucleolar RNA host genes (SNHGs) in HCC pathogenesis.
Main Methods:
- A systematic literature review was conducted using PubMed, Embase, and Cochrane databases up to August 12, 2019.
- Included studies focused on the correlation between SNHGs and HCC (26 studies) and snoRNAs and HCC (8 studies).
- A correlation network diagram was constructed to visualize the relationships between snoRNAs and HCC.
Main Results:
- Specific SNHGs (e.g., SNHG1, SNHG6, SNHG16, SNHG20) exhibit diverse roles in HCC, promoting or inhibiting tumorigenesis.
- SNORD76 promotes tumor cell proliferation, and its pathway overlaps with snoU2_19.
- Several snoRNAs and SNHGs (SNHG3, SNHG20, SNHG6, SNORD76, snoRA47, SNHG16, snoU2_19) modulate epithelial-mesenchymal transition (EMT) and the Wnt/β-catenin signaling pathway in HCC.
Conclusions:
- snoRNAs regulate HCC occurrence by modulating multiple molecular signaling pathways.
- snoRNAs demonstrate potential as molecular targets for HCC therapy.
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