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[Post-denervation changes in the membrane potentials of muscle fibers in cold-adapted rats]
Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova
|August 1, 1988
Abstract:
In rats, the resting and active MPs of single muscle fibers of fast (m. gastrocnemius) and slow (m. soleus) denervated muscles were measured in cold-adapted and control animals. Electrophysiological characteristics of muscle fibers were studied within 10 days after dissection of the sciatic nerve. Postdenervation changes in the control group were less obvious in the fast fibers, whereas in cold-adapted rats they were lesser in the slow muscle fibers.
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01:24Generation of Action Potential in Skeletal Muscles
Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the cell's...
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the cell's...
01:29Relaxation of Skeletal Muscles
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open.