Related Experiment Video
Updated: Dec 30, 2025
10:28
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.4K
Gastric Cancer in History: A Perspective Interdisciplinary Study
Skender Topi1,2, Luigi Santacroce3,4, Lucrezia Bottalico4
1Department of Clinical Disciplines, School of Technical Medical Sciences, University of Elbasan "A. Xhuvani", 3001 Elbasan, Albania.
Cancers
|January 26, 2020
Summary
Gastric cancer, a major global health concern, has evolved from ancient observations to modern understanding. Discoveries like Helicobacter pylori have significantly improved treatment outcomes for this deadly disease.
Area of Science:
- Gastroenterology
- Oncology
- Medical History
Background:
- Gastric adenocarcinoma is the 4th most common cancer and 2nd leading cause of cancer death globally.
- Understanding its pathogenic mechanisms is recent and continually evolving.
Purpose of the Study:
- To investigate the historical understanding of gastric cancer's physiopathology.
- To trace the evolution of knowledge in gastroenterological, pharmacological, and surgical fields.
- To define how gastric cancer became a more curable disease over time.
Main Methods:
- Examined historical knowledge of gastric cancer from ancient civilizations to modern times.
- Assessed understanding based on visual analysis, progressing to histological and pathophysiological examination.
- Reviewed advancements in gastroenterology, pharmacology, and surgery related to gastric cancer.
Main Results:
- Ancient civilizations recognized cancer but attributed causes to environmental factors and supernatural influences.
- The Renaissance spurred discoveries through autopsies and endoscopy, improving visual analysis.
- Key advancements include the first gastric surgery (1879) and the discovery of Helicobacter pylori's role in peptic ulcer disease and gastric lymphoma.
Conclusions:
- Gastric cancer has ancient origins, with evolving etiological hypotheses influencing therapy.
- 20th-century scientific progress elucidated causes, notably the role of Helicobacter pylori.
- Current research explores other microorganisms and probiotic modulation in gastric cancer physiopathology.
Related Concept Videos
01:50What is Monogastric Digestion?
74.8K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.8K
01:17Gastritis-II: Pathophysiology
1.1K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.1K
01:27Gastritis-I: Introduction and Types
2.0K
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
2.0K
01:28Peptic Ulcer Disease II: Pathophysiology
1.8K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
1.8K
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
473
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
473