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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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Related Experiment Video

Updated: Dec 30, 2025

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

Long Noncoding RNA in Myeloid and Lymphoid Cell Differentiation, Polarization and Function.

Imran Ahmad¹, Araceli Valverde¹, Fayek Ahmad¹

¹Mucosal Immunology Lab, College of Dentistry, University of Illinois at Chicago, Chicago 60612, IL, USA.

|January 26, 2020

Summary

Long noncoding RNAs (lncRNAs) are crucial regulators of immune cell development and function. This review details their roles in myeloid and lymphoid cell differentiation, offering potential diagnostic and therapeutic targets for immune diseases.

Keywords:

immune responses long noncoding RNA lymphoid cells myeloid cells polarization

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Last Updated: Dec 30, 2025

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

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Published on: November 11, 2014

Chromatin Isolation by RNA Purification ChIRP

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Published on: March 25, 2012

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

Area of Science:

Immunology
Molecular Biology
Genetics

Background:

Long noncoding RNAs (lncRNAs) are abundant non-protein coding RNAs with largely unknown functions.
lncRNAs exhibit specific expression patterns across tissues, cells, and developmental stages.
Emerging evidence highlights lncRNA involvement in immune cell lineage commitment and immune responses.

Purpose of the Study:

To review the mechanistic roles of lncRNAs in immune cell differentiation, polarization, and activation.
To elucidate the involvement of lncRNAs in myeloid and lymphoid cell biology.
To identify lncRNAs as potential targets for immune cell-related diseases.

Main Methods:

Literature review of studies investigating lncRNA function in immune cells.
Analysis of lncRNA expression patterns in myeloid and lymphoid cell differentiation.
Mechanistic insights into lncRNA regulation of immune cell processes.

Main Results:

lncRNAs directly participate in the differentiation, polarization, and activation of myeloid cells (monocytes, macrophages, dendritic cells).
lncRNAs play significant roles in the development and function of lymphoid cells (T cells, B cells, NK cells).
Dysregulated lncRNA expression is associated with various immune cell-related conditions.

Conclusions:

lncRNAs are critical regulators of immune cell homeostasis and function.
Further research is needed to fully understand lncRNA mechanisms in immunity.
lncRNAs represent promising targets for novel diagnostics and therapeutics in immune diseases.