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Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review
Omowumi T Kayode1, Damilare E Rotimi1, Abolanle A A Kayode2
1Department of Biochemistry, College of Pure and Applied Sciences, Landmark University, P.M.B 1001, Omu Aran 251101, Nigeria.
Toxics
|January 26, 2020
Summary
Monosodium glutamate (MSG) can cause male reproductive dysfunction through various mechanisms, including sperm damage and hormonal imbalance. This review explores these effects and potential treatments for MSG-induced reproductive issues.
Area of Science:
- Reproductive Biology
- Toxicology
- Endocrinology
Background:
- Reproductive dysfunction and infertility affect couples trying to conceive.
- Factors contributing to reproductive issues include nutrition, drugs, diseases, and toxicants.
- Monosodium glutamate (MSG), a common food additive, is implicated in male reproductive anomalies.
Purpose of the Study:
- To review the mechanisms by which MSG induces reproductive dysfunction in males.
- To discuss treatment strategies for mitigating MSG's toxic effects on reproduction.
Main Methods:
- Literature review of studies investigating MSG's impact on male reproductive health.
- Analysis of established mechanisms of MSG-induced reproductive toxicity.
Main Results:
- MSG can lead to spermatogenic alterations (low sperm count, high abnormality, reduced motility, decreased pH).
- It causes oxidative damage (increased lipid peroxidation, reduced antioxidant enzymes).
- Histological changes (hemorrhage, germ/Sertoli cell distortion) and hormonal imbalance (reduced testosterone, LH, FSH) are observed.
Conclusions:
- MSG exerts detrimental effects on male reproductive parameters through multiple pathways.
- Understanding these mechanisms is crucial for developing therapeutic interventions against MSG-induced reproductive dysfunction.
