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Updated: Dec 30, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Base Promoted Intumescence of Phenols
Yu Ji1,2, Qiang Yao1,2,3, Weihong Cao1
1Ningbo Key Laboratory of Polymer Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Abstract:
: The intumescent process of sodium (substituted) phenolates has been studied. The generation of hydrogen radical via a homolytic cleavage of the Ar-H bond and the subsequent hydroarylation of phenolates to cyclohexadienes along with cyclization and elimination reactions of cyclohexadienes are critical steps in the base promoted intumescence of phenols. The substituents show great influence on the intumescence of phenolates. Phenolates substituted with a weak electron donating group enable intumescence while those with an electron withdrawing group or strong electron donating group suppresses intumescence. This distinction can be justified by both electronic and steric effects of substituents on the generation of hydrogen radical and the degree of hydroarylation.
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