The inheritance mode of simian-type E, F, and GH blood groups in cynomolgus monkeys

The mode of inheritance of four different red cell antigens (E^cy, F^cy, G^cy, and H^cy), detected by alloimmune reagents prepared by us for the cynomolgus monkey, was studied. The results of the segregation analysis suggest that each antigen is inherited in an autosomal dominant manner. Both the random sample analysis and family study revealed that two of these red cell antigens (E^cy and F^cy) probably represent the products of two independent genes while the expression of the other two antigens (G^cy and H^cy is governed by two autosomal codominant alleles. Thus, three simian-type blood group systems could be demonstrated by the four newly developed alloimmune reagents. We use the following nomenclature for these blood groups: the E and F blood groups, each with two phenotypes, antigen positive (E and F) and antigen negative (e and f), and the GH blood group having three phenotypes (G, H, and GH).