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Updated: Dec 30, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
30.9K
Relationship between gut microbiota composition and sensitization to inhaled allergens
Ayami Nomura1, Atsushi Matsubara1, Sinichi Goto1
1Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Summary
Gut bacteria composition influences allergic sensitization. Specific bacterial orders like Bacteroidales, Lactobacillales, and Bifidobacteriales may impact immune responses to inhaled allergens such as Japanese cedar pollen and house dust.
Area of Science:
- Microbiome research
- Immunology
- Allergen sensitization
Background:
- Gut microbiota dysbiosis is linked to allergic diseases.
- Understanding the gut microbiome's role in sensitization to inhaled allergens is crucial.
Purpose of the Study:
- To investigate the association between gut microbiota composition and sensitization to Japanese cedar pollen (JCP) and house dust (HD).
- To identify specific bacterial orders that correlate with sensitization to inhaled antigens.
Main Methods:
- Analysis of fecal bacterial 16S rRNA sequencing in 1109 participants.
- Comparison of gut microbial composition between sensitized and unsensitized groups for JCP and HD.
- Measurement of antigen-specific IgE levels against JCP and HD.
Main Results:
- Higher Bacteroidales composition was observed in JCP-sensitized individuals.
- Lactobacillales was higher in HD-unsensitized individuals.
- Low Bacteroidales with high Bifidobacteriales or Lactobacillales correlated with lower HD sensitization.
Conclusions:
- Gut bacteria, including Lactobacillales, Bifidobacteriales, and Bacteroidales, may influence sensitization to inhaled allergens.
- Specific microbial compositions are associated with altered sensitization rates to common environmental allergens.
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