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Updated: Dec 30, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Antimicrobial activity of Novel spinel nanoferrites against pathogenic fungi and bacteria
Mohsen A Sayed1, H K Abdelsalam2,3, Asmaa A H El-Bassuony4
1Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt.
Abstract:
In a search for novel therapeutic agents against pathogenic fungal species, Candida in addition to bacterial species, novel spinel nanoferrites were assayed against four pathogenic fungi isolated from different clinical samples of ear and skin infections: Aspergillus flavus, A. niger, A. terrus and A. fumigatus, four Candia species: Candida albicans, C. parapsilosis, C. krusei and C. tropicales, and four bacterial species: two Gram +ve: Bacillus subtilis and Streptococcus pyogenes, and two Gram -ve: Pseudomonas vulgaris and Escherichia coli. It was found that the assayed compounds displayed different levels of antifungal and antibacterial activities against all tested microorganisms. The antimicrobial potency depends on the method of synthesis of the nanoparticles and also on the microbial species.
Insights
Novel spinel nanoferrites show promising antifungal and antibacterial activities against various clinical pathogens. Antimicrobial effectiveness varies based on nanoparticle synthesis and the specific microbial species targeted.
Area of Science:
- Materials Science
- Nanotechnology
- Microbiology
Background:
- Pathogenic fungal and bacterial infections pose significant health risks.
- Development of novel antimicrobial agents is crucial for combating resistant strains.
- Spinel nanoferrites are being explored for their therapeutic potential.
Purpose of the Study:
- To synthesize and evaluate novel spinel nanoferrites as antimicrobial agents.
- To assess the efficacy of these nanoferrites against pathogenic fungi and bacteria.
- To investigate the influence of synthesis methods on antimicrobial activity.
Main Methods:
- Synthesis of novel spinel nanoferrites.
- Antimicrobial susceptibility testing against Aspergillus and Candida species.
- Antibacterial assays against Gram-positive and Gram-negative bacteria.
Main Results:
- The synthesized spinel nanoferrites exhibited varying degrees of antifungal activity against Aspergillus and Candida species.
- Significant antibacterial effects were observed against both Gram-positive and Gram-negative bacteria.
- Antimicrobial potency was found to be dependent on the nanoparticle synthesis method and the specific microorganism.
Conclusions:
- Novel spinel nanoferrites demonstrate potential as broad-spectrum antimicrobial agents.
- The synthesis route significantly impacts the antimicrobial efficacy of nanoferrites.
- Further research is warranted to optimize nanoferrite properties for therapeutic applications.
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