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Updated: Dec 30, 2025

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Second Hits in Dilated Cardiomyopathy.
Peter Marstrand1,2, Kermshlise Picard1, Neal K Lakdawala3
1Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Genetic mutations are found in 10-20% of secondary dilated cardiomyopathy (DCM) cases, similar to primary DCM. Identifying these genetic causes, like TTN mutations, is crucial for understanding patient outcomes and future management strategies.
Area of Science:
- Cardiology
- Genetics
- Molecular Biology
Background:
- Dilated cardiomyopathy (DCM) is increasingly linked to genetic factors.
- Recent research highlights genetic causes in DCM secondary to environmental exposures.
Purpose of the Study:
- To review the genetic basis of DCM caused by alcohol, anthracyclines, and pregnancy.
- To explore the influence of exercise on secondary DCM genetic modifiers.
Main Methods:
- Literature review of genetic studies in DCM.
- Analysis of genetic architecture in secondary DCM.
- Examination of gene mutation frequencies and types.
Main Results:
- Genetic mutations are found in 10-20% of secondary DCM cases, comparable to primary DCM.
- TTN (titin) is the most frequently mutated gene.
- Clinical outcomes vary based on the presence of identifiable mutations.
Conclusions:
- Genetic factors play a significant role in secondary DCM.
- Genetic screening is recommended for presumed secondary DCM.
- Further research is needed for managing patients with DCM mutations during pregnancy or cardiotoxin exposure.
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