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Emerging NIR light-responsive delivery systems based on lanthanide-doped upconverting nanoparticles.

Xuan Thien Le1, Yu Seok Youn2

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This summary is machine-generated.

Lanthanide-doped upconversion nanoparticles (UCNPs) offer advanced nanomedicine capabilities for targeted drug delivery and bioimaging. These light-responsive nanomaterials enhance therapeutic effectiveness and overcome resistance through photon-triggered mechanisms.

Keywords:
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Area of Science:

  • Nanomedicine
  • Biotechnology
  • Materials Science

Background:

  • Lanthanide (Ln)-doped upconversion nanoparticles (UCNPs) are emerging nanomedicine materials.
  • UCNPs convert near-infrared light into UV/VIS emissions, enabling deeper tissue penetration and lower toxicity compared to conventional systems.
  • They are valuable for light-responsive drug delivery, offering temporal and spatial control.

Purpose of the Study:

  • To review recent advancements in UCNP-based nanoplatforms.
  • To highlight their applications in phototherapy, chemotherapy, and bioimaging.
  • To discuss modification methods, diagnostics, and design strategies for UCNPs.

Main Methods:

  • Review of literature on UCNP modification and application in nanomedicine over the last decade.
  • Analysis of UCNP-based systems for drug delivery, bioimaging, and phototherapy.
  • Focus on photon-triggered therapeutic mechanisms and overcoming therapy resistance.

Main Results:

  • UCNPs demonstrate significant potential in enhancing therapeutic effectiveness and overcoming resistance when combined with various materials and delivery strategies.
  • UCNPs serve dual roles as optical probes for bioimaging and therapeutic agents via photon-triggered mechanisms.
  • Recent progress shows improved modification methods, diagnostic tools, and nanoplatform designs for UCNPs.

Conclusions:

  • UCNP-based nanoplatforms represent a promising frontier in nanomedicine, offering versatile applications in diagnostics and therapeutics.
  • Their unique light-responsive properties facilitate controlled drug release and enhanced treatment outcomes.
  • Continued research in UCNP modification and design is crucial for advancing phototherapy, chemotherapy, and bioimaging.