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Related Concept Videos

Genomics02:02

Genomics

39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Updated: Dec 30, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Genomic profiling in oncology clinical practice.

N Rodríguez1, D Viñal2, J Rodríguez-Cobos3

  • 1Department of Medical Oncology, Hospital Universitario La Paz, Catedra UAM-Medicina de Innovación, Madrid, Spain.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|January 26, 2020
PubMed
Summary
This summary is machine-generated.

Genomic profiling using next-generation sequencing is increasingly used in oncology for diagnosis and treatment. This technology offers new therapeutic options for cancer patients by analyzing tumor genetics.

Keywords:
Genomic profilingHereditary cancer syndromesLiquid biopsyNext-generation sequencingSanger sequencing

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • High-throughput sequencing technologies have advanced rapidly, reducing costs.
  • Genomic profiling is becoming integral to routine oncology practice.

Purpose of the Study:

  • To review the clinical applications of genomic profiling in oncology.
  • To discuss the limitations of genomic profiling in clinical settings.
  • To focus on next-generation sequencing (NGS) applications.

Main Methods:

  • Review of current literature on genomic profiling in oncology.
  • Focus on next-generation sequencing (NGS) methodologies.
  • Analysis of clinical utility and limitations.

Main Results:

  • Genomic profiling aids in genetic counseling, cancer diagnosis, and molecular characterization.
  • It serves as a biomarker for prognosis and treatment response.
  • Germline or somatic tumor characterization can reveal novel treatment avenues.

Conclusions:

  • Genomic profiling, particularly via NGS, is a valuable tool in modern oncology.
  • Understanding its applications and limitations is crucial for effective clinical implementation.
  • It holds significant promise for personalized cancer therapy.