Therapeutic plasma exchange for exogenous insulin antibody syndrome in combined variable immunodeficiency: a case

Daniel J Robbins1, Natalie E Taylor1, Damodaran Narayanan1

  • 1Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI.

A 32-year-old male with type I diabetes presented with profound hypoglycemia due to exogenous insulin antibody syndrome in the setting of newly-diagnosed common variable immunodeficiency. Immunomodulatory therapy was not initially effective, but after the initiation of plasma exchange hypoglycemia resolved, and glucose lability improved.

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