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Related Experiment Video

Updated: Dec 30, 2025

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Interferon lambda 1 is associated with dengue severity in Thailand.

Unchana Arayasongsak1, Izumi Naka2, Jun Ohashi2

  • 1Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Bangkok 10400, Thailand.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|January 26, 2020
PubMed
Summary
This summary is machine-generated.

A specific variant (rs7247086) in the interferon lambda 1 (IFNL1) gene was found to protect against dengue hemorrhagic fever (DHF) in children. This finding suggests IFNL1 plays a role in dengue disease severity.

Keywords:
DengueDisease severityGenetic associationIFNL1

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Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • Dengue infection presents with a spectrum of illness, from dengue fever (DF) to severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS).
  • Host genetic factors are implicated in determining dengue disease severity.
  • The interferon lambda 1 (IFNL1) gene is a potential candidate for influencing immune responses to viral infections.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the IFNL1 gene and the severity of dengue infection.
  • To identify host genetic factors contributing to the differential outcomes of dengue disease in a Thai pediatric population.

Main Methods:

  • A case-control association study was conducted with 877 pediatric patients diagnosed with DF, DHF, or DSS.
  • Genotyping of two IFNL1 SNPs (rs30461 and rs7247086) was performed using TaqMan real-time PCR.

Main Results:

  • The IFNL1 rs7247086 variant showed a significant association with protection against dengue hemorrhagic fever (DHF).
  • Carriers of the CT and TT genotypes, as well as the T allele at rs7247086, exhibited a reduced risk of developing DHF (p=0.03 and p=0.01, respectively).
  • The other tested SNP (rs30461) did not show a significant association with DHF or DSS.

Conclusions:

  • The T allele of IFNL1 rs7247086 is a protective factor against the development of dengue hemorrhagic fever (DHF).
  • These findings suggest that IFNL1 plays a role in the pathogenesis of DHF and may influence dengue disease progression.