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Related Experiment Video

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Towards Predicting Progression to Severe Dengue.

Makeda Robinson1, Shirit Einav1

  • 1Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Trends in Microbiology
|January 27, 2020
PubMed
Summary
This summary is machine-generated.

Predicting severe dengue infection is crucial. New biomarkers, including gene sets and antibody properties, show promise for developing prognostic assays to improve patient care and resource allocation in endemic areas.

Keywords:
biomarkersdengueprognosticstranscriptomicsvirus–host interactions

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Area of Science:

  • Virology
  • Immunology
  • Epidemiology

Background:

  • Dengue infection poses a significant global health threat, with 5-20% of symptomatic cases progressing to severe disease.
  • Severe dengue is associated with substantial morbidity and mortality, necessitating early identification and intervention.
  • Current diagnostic tools lack prognostic capabilities to predict disease severity.

Purpose of the Study:

  • To review recent discoveries of potential biomarkers for predicting dengue disease progression.
  • To explore the utility of gene sets, anti-dengue antibody properties, and inflammatory markers as prognostic indicators.
  • To highlight the need for validated biomarkers to develop predictive assays for severe dengue.

Main Methods:

  • Literature review of recent scientific discoveries related to dengue biomarkers.
  • Analysis of gene sets, anti-dengue antibody characteristics, and inflammatory markers.
  • Assessment of potential clinical utility for prognostic assay development.

Main Results:

  • Several gene sets, anti-dengue antibody properties, and inflammatory markers have been identified with potential prognostic value.
  • These biomarkers may indicate a patient's risk of progressing to severe dengue infection.
  • Further large-scale validation is required to confirm their predictive accuracy.

Conclusions:

  • Identified biomarkers offer promising avenues for developing the first prognostic assay for severe dengue.
  • Validated prognostic assays can significantly improve patient management and healthcare resource allocation.
  • Development of affordable, sample-to-answer technologies is key for implementation in dengue-endemic regions.