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Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
Published on: April 15, 2014
PRES-like presentation in MOG antibody-related demyelination (MARD)
Joel Corbett1, Sandeep Bhuta2, Kerri Prain3
1Department of Neurology, Gold Coast University Hospital, Southport, QLD 4215, Australia.
Abstract:
A 33-year-old male presented with a progressive four-week history of frontal headache and left visual field impairment. MRI brain confirmed bilateral, asymmetric, occipital vasogenic oedema, suggestive of posterior reversible encephalopathy syndrome (PRES). Serum testing for MOG antibodies was positive, confirming a diagnosis of MOG antibody-related demyelination (MARD). A similar PRES-like pattern of white matter inflammation has been reported previously in neuromyelitis optica spectrum disorder but has not previously been reported in MARD.
Insights
Posterior reversible encephalopathy syndrome (PRES) was observed in a patient with MOG antibody-related demyelination (MARD). This PRES-like pattern is a novel finding in MARD, previously only seen in neuromyelitis optica spectrum disorder.
Area of Science:
- Neuroimmunology
- Neurology
- Radiology
Background:
- Posterior reversible encephalopathy syndrome (PRES) is a neurological condition characterized by vasogenic edema.
- It has been associated with neuromyelitis optica spectrum disorder (NMOSD).
- MOG antibody-related demyelination (MARD) is an autoimmune disorder affecting the central nervous system.
Observation:
- A 33-year-old male presented with headache and visual field impairment.
- Brain MRI revealed bilateral occipital vasogenic edema, consistent with PRES.
- The patient tested positive for MOG antibodies, confirming MARD.
Findings:
- This case presents a PRES-like pattern of white matter inflammation in MARD.
- This radiological finding has not been previously reported in MARD.
- The presentation mimics patterns seen in NMOSD.
Implications:
- This finding expands the spectrum of clinical and radiological presentations of MARD.
- It suggests potential overlapping pathophysiological mechanisms between MARD and NMOSD.
- Further research is needed to understand the relationship between MOG antibodies and PRES-like phenomena.
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