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Updated: Dec 30, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Nuclear Receptors in Cancer Inflammation and Immunity

Linjie Zhao1, Hongbo Hu2, Jan-Åke Gustafsson3

  • 1Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education (MOE), and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, and Collaborative Innovation Center, Chengdu, PR China.

Trends in Immunology
|January 27, 2020
PubMed

Insights

Nuclear receptors (NRs) influence cancer by regulating inflammation and immunity within the tumor microenvironment. Understanding these NR roles offers potential for new cancer therapies.

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Nuclear receptors (NRs) are key regulators of cellular functions with significant implications for cancer development.
  • NRs play a critical role in the tumor microenvironment, influencing inflammation and immune responses.
  • Dysregulation of NR activity is linked to various cancer hallmarks.

Purpose of the Study:

  • To summarize recent findings on how NR activity controls tumor inflammation.
  • To elucidate the roles of different NRs in modulating tumor immunity.
  • To explore the biological characteristics of NR-expressing immune cells in cancer.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Analysis of mechanisms by which NRs impact tumor inflammation.
  • Examination of NR expression in immune cells within the tumor context.

Main Results:

  • NRs employ diverse mechanisms to control tumor-associated inflammation.
  • Specific NRs differentially modulate anti-tumor immunity and immune cell functions.
  • NR activity significantly impacts the composition and behavior of immune infiltrates.

Conclusions:

  • NR-dependent modulation of tumor inflammation and immunity presents therapeutic opportunities.
  • Targeting NRs could lead to novel strategies for cancer treatment.
  • Further research into NR functions in cancer immunity is warranted.

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