Related Experiment Video
Updated: Dec 30, 2025
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
4.5K
Diagnostic and treatment delay in primary hyperparathyroidism. A pending issue
Miguel Paja-Fano1, Adela-Leyre Martínez-Martínez1, Andoni Monzón-Mendiolea1
1Hospital Universitario Basurto. Servicio de Endocrinología, Osakidetza, OSI Bilbao-Basurto, Bilbao, España.
Endocrinologia, Diabetes Y Nutricion
|January 27, 2020
Summary
Primary hyperparathyroidism (PHPT) is often diagnosed late, with patients experiencing significant delays in receiving care. This delay in diagnosis and treatment for PHPT contributes to increased kidney disease.
Area of Science:
- Endocrinology
- Nephrology
- Surgical Patient Care
Background:
- Primary hyperparathyroidism (PHPT) is frequently underdiagnosed in hypercalcemic patients.
- Delayed diagnosis of PHPT can lead to increased patient morbidity.
Purpose of the Study:
- To identify overlooked hypercalcemia and surgical criteria for PHPT in patients operated on.
- To determine if diagnostic delays for PHPT lead to increased morbidity.
Main Methods:
- Observational study of 116 consecutive patients.
- Evaluation of electronic medical records at least 12 months prior to endocrinology referral.
- Categorization into four groups based on calcium levels and surgical criteria.
Main Results:
- Over 72% had prior serum calcium measurements; 57% had hypercalcemia.
- 37% of hypercalcemic patients met criteria for surgery (CFS), with an average diagnostic delay of 57 months.
- Patients with PHPT and CFS were younger and had higher rates of nephrolithiasis and renal impairment.
Conclusions:
- Referral for PHPT with CFS averages a 5-year delay, often due to unrecognized hypercalcemia or surgical criteria.
- This delay contributes to kidney disease.
- Interventions are necessary to expedite PHPT diagnosis and treatment.
Keywords:
DiagnosisDiagnostic delayDiagnósticoHipercalcemiaHiperparatiroidismo primarioHypercalcemiaPrimary hyperparathyroidismRetraso diagnósticoRetraso terapéuticoTherapeutic delayMore Related Videos
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
283
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
283
01:30Urinary Tract Calculi III: Medical Management
145
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
145
00:59The Parathyroid Glands
4.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
4.2K
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
279
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
279
01:26Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
382
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
382
01:27Peripheral Artery Disease III: Interprofessional Care
187
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
187