Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective
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Updated: Dec 30, 2025

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
Published on: September 25, 2016
Wen-Kai Hsiao1, Theresa R Hörmann2, Peter Toson3
1Research Center Pharmaceutical Engineering GmbH, Graz, Austria; European Consortium of Continuous Pharmaceutical Manufacturing (eccpm.com).
Abstract:
The pharmaceutical industry today is experiencing a paradigm shift from batch to continuous manufacturing, which promises greater flexibility to target diverse populations, as well as more-consistent product quality to ensure best efficacy. However, shifting to continuous processing means that even basic process steps, such as feeding, can become unexpected but are crucially important. In this review, we will present the fundamental differences between dispensing (batch) and feeding (continuous) and how they impact the formulation design space. We will further outline our rational development approach, applicable to continuous unit operations in general, which includes standardized material and process characterization, as well as predictive modeling based on advanced, multidomain simulation tools.
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