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Mirogabalin prevents repeated restraint stress-induced dysfunction in mice
Takashi Iwai1, Akinori Kikuchi1, Misa Oyama1
1Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Behavioural Brain Research
|January 27, 2020
Summary
Mirogabalin, a gabapentinoid, was found to protect against stress-induced memory deficits and anxiety in mice. It also normalized intestinal function, suggesting central nervous system involvement in stress response.
Area of Science:
- Neuroscience
- Pharmacology
- Stress Research
Background:
- Gabapentinoids are used for pain and anxiety.
- Stress can trigger and worsen psychiatric disorders.
- Mirogabalin is a novel gabapentinoid.
Purpose of the Study:
- To investigate mirogabalin's neuroprotective effects against stress.
- To determine if mirogabalin protects brain functions from repeated stress.
- To explore mirogabalin's impact on anxiety and memory.
Main Methods:
- Adult male mice underwent restraint stress.
- Mirogabalin was administered systemically or centrally.
- Cognitive function, anxiety, and hippocampal activity (c-Fos) were assessed.
- Intestinal function was measured via defecation and fecal output.
Main Results:
- Repeated stress caused memory dysfunction, anxiety, and altered gut function.
- Mirogabalin prevented these stress-induced changes.
- Stress increased hippocampal c-Fos expression, which mirogabalin reduced.
- Mirogabalin's effects on gut function involved the central nervous system.
Conclusions:
- Mirogabalin protects against stress-induced cognitive and anxiety-like behaviors.
- Mirogabalin normalizes stress-related intestinal dysfunction.
- The neuroprotective effects may involve inhibiting hippocampal hyperactivity.
