Processing of Targets and Non-targets in Verbal Working Memory

In this study we used functional MRI (fMRI) to examine whether defining a stimulus as a target affects brain activation associated with a verbal working memory (WM) task. Seventeen healthy right-handed volunteers performed a Sternberg task with three consonants as memory set. We performed a region of interest based fMRI analysis to examine differences in brain activity patterns between targets and non-targets. Non-target brain activity was subtracted from target activity and hemispheric and fronto-parietal differences were tested by conducting a MANOVA. Participants responded correctly to 97.5% of the stimuli. The fMRI results showed a hemisphere by fronto-parietal location interaction, where targets evoked increased activity in the right frontal regions compared to non-targets, whereas the left frontal task activation did not differ between targets and non-targets. In the parietal regions, targets evoked increased activity compared to non-targets in the lateral anterior, but not the medial posterior part. Our study revealed that defining a stimulus as a target within a verbal WM task evokes an increase in brain activity in right frontal brain regions, compared to non-targets. Our results suggest an important hemispheric differentiation in target processing, in which the right frontal cortex is predominantly involved in processes associated with target stimuli. The left frontal cortex does not differentiate between processing target and non-target stimuli, suggesting involvement in WM processes that are independent of stimulus type. Parietal, the lateral anterior part is predominantly involved in target processing, while the medial posterior part does not differentiate between target and non-target processing.