Repurposing drugs in oncology: From candidate selection to clinical adoption

Area of Science:

• Oncology
• Pharmacology
• Drug Development

Background:

• Drug repurposing leverages existing pharmaceuticals for novel therapeutic applications.
• This strategy is increasingly vital for developing new cancer treatments efficiently.
• It encompasses drug identification, clinical trials, regulatory approval, and market integration.

Purpose of the Study:

• To outline a literature-based methodology for selecting candidate drugs for repurposing.
• To examine challenges in clinical development, drug licensing, reimbursement, and adoption.
• To provide illustrative examples in osteosarcoma, pancreatic cancer, and perioperative therapies.

Main Methods:

• A comprehensive literature review was conducted to identify and analyze drug repurposing strategies.
• Case studies focusing on osteosarcoma, pancreatic cancer, and perioperative treatments were examined.
• Key obstacles in the drug repurposing pipeline were identified and discussed.

Main Results:

• A systematic approach to candidate drug selection can accelerate the repurposing process.
• Significant challenges exist in clinical trial design, regulatory pathways, and market access for repurposed drugs.
• Successful drug repurposing requires overcoming scientific, regulatory, and economic barriers.

Conclusions:

• Drug repurposing is a promising avenue for novel cancer therapies, but requires strategic planning.
• Addressing hurdles in clinical development and regulatory approval is crucial for successful implementation.
• Further research and collaboration are needed to optimize the drug repurposing pipeline for oncology.