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pH-stimulus response dye-cucurbituril sensor for amino acids in aqueous solution
Mei-Xiang Yang1, Qing Tang2, Mei Yang1
1Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|January 27, 2020
Summary
This study introduces a novel pH-stimulus supramolecular sensor using inverted cucurbit[7]uril (iQ[7]) and 4-(4-dimethylaminostyryl) quinoline (DSQ) to detect l-α-amino acids.
Area of Science:
- Supramolecular Chemistry
- Analytical Chemistry
- Chemical Sensing
Background:
- Host-guest chemistry offers versatile platforms for molecular recognition.
- Cucurbiturils are macrocyclic hosts with unique binding properties.
- Fluorescent sensors are crucial for detecting biomolecules.
Purpose of the Study:
- To develop a pH-stimulus response supramolecular sensor.
- To utilize inverted cucurbit[7]uril (iQ[7]) and 4-(4-dimethylaminostyryl) quinoline (DSQ) for sensing.
- To discriminate between structurally similar l-α-amino acids in aqueous solutions.
Main Methods:
- Formation of host-guest inclusion complexes between iQ[7] and DSQ.
- Investigation of complexation at different pH values.
- Spectroscopic analysis (fluorescence) to monitor sensing events.
Main Results:
- Complexation of DSQ within iQ[7] enhanced fluorescence.
- Formation of distinct iQ[7]-DSQ complexes with varying colors at different pHs.
- Differential affinities of DSQ@iQ[7] sensors for l-α-amino acids were observed, dependent on pH.
Conclusions:
- A novel pH-stimulus response supramolecular sensor system was successfully developed.
- The iQ[7]-DSQ complex demonstrates potential for discriminating l-α-amino acids.
- This approach offers a promising method for analyzing amino acids in aqueous environments.
